Check out this article for information on how to make Front Row an even better experience.
Here are the tips you will find:
1. Sync the remote with only one computer.
2. Open and close Front Row using keyboard
3. Installing Front Row on any Mac running Mac OS X (10.4.5 and above)
4. Use the Front Row Remote to control other applications
5. Play Xvid, DivX, and 3ivX using Front Row
6. Using Front Row to play media on external drives
7. Play movies from VIDEO_TS folders